Allison Xu, PhD

Professor

Diabetes Center

+1 415 476-2807

Research in Allison Xu’s laboratory focuses on understanding the adaptive regulation of energy balance and glucose homeostasis in response to changes of physiologic and environmental conditions. Specifically, Allison’s lab is investigating how hypothalamic and hindbrain neurons sense and integrate peripheral hormones and nutritional signals, and how these neurons regulate feeding, energy expenditure, systemic glucose and lipid metabolism. These efforts will help better understand how energy balance and glucose homeostasis are regulated and how these regulations are disrupted in obesity, type 2 diabetes and aging.

Publications:

Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.

Diabetes

Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG, Xu AW

Functional role of c-Jun-N-terminal kinase in feeding regulation.

Endocrinology

Unger EK, Piper ML, Olofsson LE, Xu AW

Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake.

Proceedings of the National Academy of Sciences of the United States of America

Olofsson LE, Pierce AA, Xu AW

Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons.

Molecular endocrinology (Baltimore, Md.)

Piper ML, Unger EK, Myers MG, Xu AW

Aging, Metabolism and Emotion Center

Allison Xu, PhD

Identification of AgRP cells in the murine hindbrain that drive feeding.

Modulation of foraging-like behaviors by cholesterol-FGF19 axis.

ASB4 modulates central melanocortinergic neurons and calcitonin signaling to control satiety and glucose homeostasis.

A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.

Neuronal modulation of hepatic lipid accumulation induced by binge-like drinking.

Regulation of Hepatic Lipid Accumulation and Distribution by Agouti-Related Protein in Male Mice.

Hypothalamic Sensing of Bile Acids, a Gut Feeling.

Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.

Leptin potentiates astrogenesis in the developing hypothalamus.

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance.

Metabolic transceivers: in tune with the central melanocortin system.

AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice.

De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance.

Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.

Functional role of c-Jun-N-terminal kinase in feeding regulation.

Functional requirement of AgRP and NPY neurons in ovarian cycle-dependent regulation of food intake.

Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons.

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Allison Xu, PhD