Laurence Tecott, MD, PhD

Gene Targeting Models of Epilepsy: Technical and Analytical Considerations.

Neuropharmacology Methods in Epilepsy Research

Laurence H. Tecott

Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits.

Aging

Bonasera SJ, Arikkath J, Boska MD, Chaudoin TR, DeKorver NW, Goulding EH, Hoke TA, Mojtahedzedah V, Reyelts CD, Sajja B, Schenk AK, Tecott LH, Volden TA

Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli.

PloS one

Bonasera SJ, Schenk AK, Luxenberg EJ, Wang X, Basbaum A, Tecott LH

Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Urban DJ, Zhu H, Marcinkiewcz CA, Michaelides M, Oshibuchi H, Rhea D, Aryal DK, Farrell MS, Lowery-Gionta E, Olsen RH, Wetsel WC, Kash TL, Hurd YL, Tecott LH, Roth BL

Gai/o-coupled receptor signaling restricts pancreatic ß-cell expansion.

Proceedings of the National Academy of Sciences of the United States of America

Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS

Axonal control of the adult neural stem cell niche.

Cell stem cell

Tong CK, Chen J, Cebrián-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, García-Verdugo JM, Kriegstein A, Alvarez-Buylla A

Serotonin and the regulation of mammalian energy balance.

Frontiers in neuroscience

Donovan MH, Tecott LH

Impact of serotonin (5-HT)2C receptors on executive control processes.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Pennanen L, van der Hart M, Yu L, Tecott LH

Convergence of the insulin and serotonin programs in the pancreatic ß-cell.

Diabetes

Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS

A flexible estimating equations approach for mapping function-valued traits.

Genetics

Xiong H, Goulding EH, Carlson EJ, Tecott LH, McCulloch CE, Sen S

Behavioral indices of ongoing pain are largely unchanged in male mice with tissue or nerve injury-induced mechanical hypersensitivity.

Pain

Urban R, Scherrer G, Goulding EH, Tecott LH, Basbaum AI

The Role of 5-HT2C Receptors in the Pathophysiology and Treatment of Depression.

5-HT2C Receptors in the Pathophysiology of CNS Disease

Eliyahu Dremencov, Joost H. A. Folgering, Sandra Hogg, Laurence Tecott, Thomas I. F. H. Cremers

Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.

Journal of biomedical science

Honig G, Liou A, Berger M, German MS, Tecott LH

CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neurons.

Genes & development

Oury F, Yadav VK, Wang Y, Zhou B, Liu XS, Guo XE, Tecott LH, Schutz G, Means AR, Karsenty G

Enhanced food anticipatory activity associated with enhanced activation of extrahypothalamic neural pathways in serotonin2C receptor null mutant mice.

PloS one

Hsu JL, Yu L, Sullivan E, Bowman M, Mistlberger RE, Tecott LH

Serotonin regulates pancreatic beta cell mass during pregnancy.

Nature medicine

Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS

Serotonin activates murine alveolar macrophages through 5-HT2C receptors.

American journal of physiology. Lung cellular and molecular physiology

Mikulski Z, Zaslona Z, Cakarova L, Hartmann P, Wilhelm J, Tecott LH, Lohmeyer J, Kummer W

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure.

Cell

Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G

Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain.

PloS one

Honig G, Jongsma ME, van der Hart MC, Tecott LH

Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons.

Journal of neurodevelopmental disorders

Mao R, Page DT, Merzlyak I, Kim C, Tecott LH, Janak PH, Rubenstein JL, Sur M

Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Abdallah L, Bonasera SJ, Hopf FW, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH

Rodent Behavior: Approaches.

Encyclopedia of Neuroscience

L.H. Tecott, E.J. Nestler

A robust automated system elucidates mouse home cage behavioral structure.

Proceedings of the National Academy of Sciences of the United States of America

Goulding EH, Schenk AK, Juneja P, MacKay AW, Wade JM, Tecott LH

Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress.

Neuron

Fyffe SL, Neul JL, Samaco RC, Chao HT, Ben-Shachar S, Moretti P, McGill BE, Goulding EH, Sullivan E, Tecott LH, Zoghbi HY

It is time to take a stand for medical research and against terrorism targeting medical scientists.

Biological psychiatry

Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R

Relevance of animal models to human eating disorders and obesity.

Psychopharmacology

Casper RC, Sullivan EL, Tecott L

Expression level of 5-HT1A receptor alters firing rate and concentration-dependency in YFP-labeled 5-HT dorsal raphe neurons.

The FASEB Journal

Kayla L Metzger, Lyngine H Calizo, Alisson Stephen, Miles Berger, Laurence H Tecott, Sheryl G Beck

5-HT(1A) Receptor Null Mutant Mice Responding Under a Differential-Reinforcement-of-Low-Rate 72-Second Schedule of Reinforcement.

The open neuropsychopharmacology journal

Scott-McKean JJ, Wenger GR, Tecott LH, Costa AC

A novel method for automatic quantification of psychostimulant-evoked route-tracing stereotypy: application to Mus musculus.

Psychopharmacology

Bonasera SJ, Schenk AK, Luxenberg EJ, Tecott LH

Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors.

Endocrinology

Wade JM, Juneja P, MacKay AW, Graham J, Havel PJ, Tecott LH, Goulding EH

Serotonin and the orchestration of energy balance.

Cell metabolism

Tecott LH

Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH

Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons.

Nature neuroscience

Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ

Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.

The Journal of clinical investigation

O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC

A null mutation of the serotonin 6 receptor alters acute responses to ethanol.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Bonasera SJ, Chu HM, Brennan TJ, Tecott LH

Molecular determinants in the second intracellular loop of the 5-hydroxytryptamine-1A receptor for G-protein coupling.

Molecular pharmacology

Kushwaha N, Harwood SC, Wilson AM, Berger M, Tecott LH, Roth BL, Albert PR

Serotonin System Gene Knockouts.

The Serotonin Receptors

Miles Berger, Laurence H. Tecott

Social circuits: peptidergic regulation of mammalian social behavior.

Neuron

Storm EE, Tecott LH

Dysregulation of striatal dopamine signaling by amphetamine inhibits feeding by hungry mice.

Neuron

Cannon CM, Abdallah L, Tecott LH, During MJ, Palmiter RD

Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Cremers TI, Giorgetti M, Bosker FJ, Hogg S, Arnt J, Mørk A, Honig G, Bøgesø KP, Westerink BH, den Boer H, Wikstrom HV, Tecott LH

Neurobehavioral assessment in the information age.

Nature neuroscience

Tecott LH, Nestler EJ

Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems.

European journal of pharmacology

Giorgetti M, Tecott LH

Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice.

CNS spectrums

Tecott LH, Abdallah L

Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.

Nature neuroscience

Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF

Central serotonin and melanocortin pathways regulating energy homeostasis.

Annals of the New York Academy of Sciences

Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro J, Zigman JM, Cone RD, Elmquist JK

The genes and brains of mice and men.

The American journal of psychiatry

Tecott LH

Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice.

Diabetes

Nonogaki K, Abdallah L, Goulding EH, Bonasera SJ, Tecott LH

Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Rocha BA, Goulding EH, O'Dell LE, Mead AN, Coufal NG, Parsons LH, Tecott LH

Up-Regulation of Peroxisome Proliferator-Activated Receptors (PPAR-a) and PPAR-? Messenger Ribonucleic Acid Expression in the Liver in Murine Obesity: Troglitazone Induces Expression of PPAR-?-Responsive Adipose Tissue-Specific Genes in the Liver of Obese

Endocrinology

Riaz A. Memon, Laurence H. Tecott, Katsunori Nonogaki, Anne Beigneux, Arthur H. Moser, Carl Grunfeld, Kenneth R. Feingold

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Laurence Tecott, MD, PhD